Plenary Lecture

Plenary Lecture

The Role of Local Drug Delivery in the Treatment of Periodontal Diseases


Professor Shaila V. Kothiwale
KLE University, Nehru Nagar
Belgaum-590010, Karnataka, India
E-mail: shailakothiwale2000@yahoo.co.in


Abstract:
Purpose
Diseases of the periodontium continue to be one of the manís most wide spread afflictions. Chronic Periodontitis is one such inflammatory response to microbiological infection resulting in progressive destruction of attachment apparatus with formation of periodontal pocket. The use of controlled release local delivery device to suppress or eradicate the pathogenic microbiota or modulate the inflammatory response has attracted significant interest to limit periodontal tissue destruction. The purpose of this study is to evaluate the clinical and microbiological efficacy of Tetracycline, Metronidazole in sustained release device using non degradable Ethyl cellulose as polymers as a local drug delivery in the periodontal pocket to arrest periodontal disease.
Material and methods
3 sites per patient which bled on probing, measuring >6mm associated with molars were randomly allocated to three possible regimes.
The control site C: scaling & root planning
Site A: scaling and root planing with control release tetracycline
Site B: scaling and root planing with control release of Metronidazole.
Base line and follow up measurement (14th day) included clinical parameters with plaque index, gingival index, and probing pocket depth. The microbiological evaluation included Gram stain for cocci and bacilli, and Giemsa stain for spirochetes.
Results
In clinical parameters, gingival index revealed a reduction of 69.09% with control site, 77.27% with site A and 83.21% with site B.
Plaque index showed 64.14% reduction in control site, 65.29% in site A, 71.30% in site B and assessment of pocket depth measurement showed 2.27% reduction in control site, 3.27% in site A and 4.58% in site B.
Microbiological evaluation included the reduction of microorganisms by 56.10% in control group, 81.25% in site A and 96.09% in site B.
Conclusion
On comparison between and within sites at different intervals, statistically significant improvements were revealed in many clinical and microbiological parameters in all the 3 sites. On comparison between tetracycline plus scaling and root planning and Metronidazole plus scaling and root planning, Metronidazole plus scaling and root planning produced significantly greater effects.
The presentation also includes, presently ongoing projects on newly formulated polymers, namely Hydroxy propyl cellulose (HPC), Hydroxy propyl methyl cellulose (HPMC) and Chitosan with Ornidozole.

Brief Biography of the Speaker:
Dr. Shaila V. Kothiwale, is presently a Professor of Periodontics at KLE University, India, where she is engaged in teaching, clinical and research work. Her main area of research interests are LASERS, various bone grafts and Local Drug Delivery systems and Alternative Medicine in Periodontics.
She is presently engaged extensively in working with a new system of various polymers with incorporation of antibiotics in periodontal diseases and prevention of periodontal diseases using medicinal plants. She has authored and co-authored several scientific papers in National and International Indexed Journals. She has delivered key note lectures at different National and International platforms in various speciality conferences like Lasers, Tissue bank and Global aesthetics.
She is a member and an executive member of various organizations. At present she is working on a few chapters of Periodontology to be published under JAYPEE publication.

 

 

WSEAS Unifying the Science