Plenary Lecture

Cancer Therapy Based on Hybrid Nanostructures

Assistant Professor Mohsen Adeli
Co-author: Fatemeh Zabihi
Department of Organic Chemistry, Faculty of chemistry
Sharif University, Tehran, IRAN

Abstract: Cancer is one of the top three ''killers'' in the world which include cardiovascular diseases. Unfortunately treatment options for cancer patients are not effective and in the most cases these options lead to destruction the healthy tissues more than tumors. A promising strategy to overcome this problem is development of the effective delivery systems, for therapeutic and diagnostic agents, based on nanomaterials and nanostructures. This strategy is called "nanomedicine".
To be an effective and perfect delivery system, nanostructures should have several characteristics.
i) High functionality to conjugate multiple diagnostic and therapeutic agents on their surface and to have effective interaction with target cells.
ii) Ability to cross different barriers, especially cell and perinuclear membrane, in body
iii) Biocompatibility and water solubility
iv)Inertness against biological active molecules
v) No immunogenicity effect
vi) Stability in biological systems
vii) Release diagnostic and therapeutic agents in destination organelles
vii) Break down to biocompatible materials in destination organelle and
There are three classes of nanomaterials which promise to be particularly capable agents in the detection, diagnosis, and treatment of cancer (Scheme 1).
i) dendritic polymers (DPs), ii) carbon nanotubes (CNTs) and iii) quantum dots (QDs)
Although delivery systems based on these nanomaterials are valuable and sometimes effective, but they suffer several disadvantages and can not taken into account as perfect delivery systems for drugs or diagnostic agents.
However a very young and promising strategy to overcome disadvantages of above delivery systems and produce perfect targeted delivery systems for drugs or diagnostic agents is to make hybrid systems containing all mentioned nanomaterials. This strategy leads to new nano-scale materials called "hybrid nanostructures".
Hybrid functional nanostructures containing CNTs, DPs and QDs are synthesized and characterized by our group recently (Scheme 2) [1]. Short-term in vitro cytotoxicity and hemocompatibility tests has been conducted on HT1080 cell line (human Fibrosarcoma), in order to investigate their potential application in nanomedicine and to understand the limitation and capability of hybrid materials as nanoexcipients in biological systems. According to the results of the in vitro cytotoxicity tests and hemolysis assay, negligible adverse effects on the HT1080 cell and also red blood cells up to 1 mg/ml concentration were observed. Anticancer drugs and antibodies were attached to the functional groups of hybrid nanomaterials and their potential application to kill different cancer cells in vitro conditions was investigated (Figure 1).

Brief Biography of the Speaker:
Mohsen Adeli is Ph.D in the Hybrid Nanostructures and their applications in nanomedicine at the Sharif University of Technology (Tehran, Iran). After a PhD in 2005 from the Tabriz University and a postdoctoral research in the Institute for Nanoscience and Nanotechnology of Sharif University of Technology he became assiatant proffesor of chemistry at Lorestan University. His research is focused on synthesis and charactrization of hybrid nanostructures containing dendrimers, carbon nanotubes, quantum dots and polyrotaxanes and their applications for cancer therapy.
Mohsen Adeli (born in Khoramabad, Iran in 1974) received his undergraduate degree in Chemistry in 1996 at the Lorestan University. He obtained his MS and PhD degree cumlaude in 1998 and 2005 at the Tabriz University respectively. He performed his Ms research in the field of polymer chemistry which was include synthesis of new types of living polymers containing 2,5-norbornadien and ethyl methacrylate monomers and preparation of di- and tri-block copolymers under the supervision of professor Ali akbar Entezami. He performed his PhD research in the field of organic chemistry with a study on the synthesis and characterization of biocompatible dendrimers and dendritic polymers under the supervision of professor Hassan Namazi. Mohsen Adeli started his carrier at Lorestan University in 2005, where he was active as assistant professor in the field of functional hybrid nanomaterials, including carbon nanotubes and dendritic polymers. Then he introduced to the Institute for Nanoscience and Nanotechnology of Sharif University of Technology for a postdoctoral research in 2007, where he initiated a research work on the hybrid functional nanomaterials, including dendritic polymers and quantum dots. He is assistant professor of Faculty of Chemistry of Sharif University of Technology now.

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